Altered distribution of I(Ca) impairs Ca release at the t-tubules of ventricular myocytes from failing hearts

In mammalian cardiac ventricular myocytes, Ca influx and release occur predominantly at t-tubules, ensuring synchronous Ca release throughout the cell. Heart failure is associated with disrupted t-tubule structure, but its effect on t-tubule function is less clear. We therefore investigated Ca influ...

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Pubblicato in:J Mol Cell Cardiol
Autori principali: Bryant, Simon M., Kong, Cherrie H.T., Watson, Judy, Cannell, Mark B., James, Andrew F., Orchard, Clive H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Academic Press 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564288/
https://ncbi.nlm.nih.gov/pubmed/26103619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.06.012
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