JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein

Primary human fibroblasts undergoing oncogene-induced or replicative senescence are known to form senescence-associated heterochromatin foci (SAHF), which can stabilize the state of senescence. The retinoblastoma (RB) protein has an important role in SAHF; cells that lack active RB pathway fail to f...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Differ
Hoofdauteurs: Zhao, L, Zhang, Y, Gao, Y, Geng, P, Lu, Y, Liu, X, Yao, R, Hou, P, Liu, D, Lu, J, Huang, B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
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Original Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563788/
https://ncbi.nlm.nih.gov/pubmed/25698448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.6
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