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Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency
Rare functional variants of ankyrin-B have been implicated in human disease, including hereditary cardiac arrhythmia and type 2 diabetes (T2D). Here, we developed murine models to evaluate the metabolic consequences of these alterations in vivo. Specifically, we generated knockin mice that express e...
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| Pubblicato in: | J Clin Invest |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4563758/ https://ncbi.nlm.nih.gov/pubmed/26168218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81317 |
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