E-cadherin Polarity Is Determined by a Multifunction Motif Mediating Lateral Membrane Retention through Ankyrin-G and Apical-lateral Transcytosis through Clathrin

We report a highly conserved motif in the E-cadherin juxtamembrane domain that determines apical-lateral polarity by conferring both restricted mobility at the lateral membrane and transcytosis of apically mis-sorted protein to the lateral membrane. Mutations causing either increased lateral membran...

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Detalhes bibliográficos
Main Authors: Jenkins, Paul M, Vasavda, Chirag, Hostettler, Janell, Davis, Jonathan Q., Abdi, Khadar, Bennett, Vann
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656260/
https://ncbi.nlm.nih.gov/pubmed/23530049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.454439
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