PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

The X-linked neurological disorder Rett syndrome (RTT) presents with autistic features and is caused primarily by mutations in a transcriptional regulator, methyl CpG–binding protein 2 (MECP2). Current treatment options for RTT are limited to alleviating some neurological symptoms; hence, more effec...

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Vydáno v:J Clin Invest
Hlavní autoři: Krishnan, Navasona, Krishnan, Keerthi, Connors, Christopher R., Choy, Meng S., Page, Rebecca, Peti, Wolfgang, Van Aelst, Linda, Shea, Stephen D., Tonks, Nicholas K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563751/
https://ncbi.nlm.nih.gov/pubmed/26214522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80323
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