Targeting the disordered C-terminus of PTP1B with an allosteric inhibitor

PTP1B, a validated therapeutic target for diabetes and obesity, plays a critical positive role in HER2 signaling in breast tumorigenesis. Efforts to develop therapeutic inhibitors of PTP1B have been frustrated by the chemical properties of the active site. We defined a novel mechanism of allosteric...

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Hlavní autoři: Krishnan, Navasona, Koveal, Dorothy, Miller, Daniel H., Xue, Bin, Akshinthala, Sai Dipikaa, Kragelj, Jaka, Jensen, Malene Ringkjøbing, Gauss, Carla-Maria, Page, Rebecca, Blackledge, Martin, Muthuswamy, Senthil K., Peti, Wolfgang, Tonks, Nicholas K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062594/
https://ncbi.nlm.nih.gov/pubmed/24845231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1528
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