Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury

We have developed a novel plasma protein analysis platform with optimized sample preparation, chromatography, and MS analysis protocols. The workflow, which utilizes chemical isobaric mass tag labeling for relative quantification of plasma proteins, achieves far greater depth of proteome detection a...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Keshishian, Hasmik, Burgess, Michael W., Gillette, Michael A., Mertins, Philipp, Clauser, Karl R., Mani, D. R., Kuhn, Eric W., Farrell, Laurie A., Gerszten, Robert E., Carr, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Special Issue Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563722/
https://ncbi.nlm.nih.gov/pubmed/25724909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M114.046813
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