Photo-activatable Cre recombinase regulates gene expression in vivo

Techniques allowing precise spatial and temporal control of gene expression in the brain are needed. Herein we describe optogenetic approaches using a photo-activatable Cre recombinase (PA-Cre) to stably modify gene expression in the mouse brain. Blue light illumination for 12 hours via optical fibe...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Schindler, Suzanne E., McCall, Jordan G., Yan, Ping, Hyrc, Krzystof L., Li, Mingjie, Tucker, Chandra L., Lee, Jin-Moo, Bruchas, Michael R., Diamond, Marc I.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563371/
https://ncbi.nlm.nih.gov/pubmed/26350769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13627
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