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Substrate-Guided Optimization of the Syringolins Yields Potent Proteasome Inhibitors with Activity Against Leukemia Cell Lines
Natural products that inhibit the proteasome have been fruitful starting points for the development of drug candidates. Those of the syringolin family have been under exploited in this context. Using the published model for substrate mimicry by the syringolins and knowledge about the substrate prefe...
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| Publié dans: | Bioorg Med Chem |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4562813/ https://ncbi.nlm.nih.gov/pubmed/26296913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.041 |
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