A multi-trimeric fusion of CD40L and gp100 tumor antigen activates dendritic cells and enhances survival in a B16-F10 melanoma DNA vaccine model

Vaccination with tumor-associated antigens can induce cancer-specific CD8+ T cells. A recent improvement has been the targeting of antigen to dendritic cells (DC) using antibodies that bind DC surface molecules. This study explored the use of multi-trimers of CD40L to target the gp100 melanoma tumor...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Gupta, Sachin, Termini, James M, Rivas, Yaelis, Otero, Miguel, Raffa, Francesca N, Bhat, Vikas, Farooq, Amjad, Stone, Geoffrey W
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562804/
https://ncbi.nlm.nih.gov/pubmed/26241951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2015.07.081
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