Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation

Beta-cell apoptosis and failure to induce beta-cell regeneration are hallmarks of type 2-like diabetes in mouse models. Here we show that islets from obese, diabetes-susceptible New Zealand Obese (NZO) mice, in contrast to diabetes-resistant C57BL/6J (B6)-ob/ob mice, do not proliferate in response t...

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Publicat a:PLoS Genet
Autors principals: Kluth, Oliver, Matzke, Daniela, Kamitz, Anne, Jähnert, Markus, Vogel, Heike, Scherneck, Stephan, Schulze, Matthias, Staiger, Harald, Machicao, Fausto, Häring, Hans-Ulrich, Joost, Hans-Georg, Schürmann, Annette
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562707/
https://ncbi.nlm.nih.gov/pubmed/26348837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005506
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