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Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer’s Disease Pathology

Amyloid beta (Aβ) oligomers associated with Alzheimer’s disease (AD) form Ca(2+)-permeable plasma membrane pores, leading to a disruption of the otherwise well-controlled intracellular calcium (Ca(2+)) homeostasis. The resultant up-regulation of intracellular Ca(2+) concentration has detrimental imp...

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Publicado en:PLoS One
Main Authors: Ullah, Ghanim, Demuro, Angelo, Parker, Ian, Pearson, John E.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562663/
https://ncbi.nlm.nih.gov/pubmed/26348728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137357
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