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Single-channel Ca(2+) imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology
Oligomeric forms of Aβ peptides are implicated in Alzheimer’s disease (AD) and disrupt membrane integrity, leading to cytosolic calcium (Ca(2+)) elevation. Proposed mechanisms by which Aβ mediates its effects include lipid destabilization, activation of native membrane channels, and aggregation of A...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3206345/ https://ncbi.nlm.nih.gov/pubmed/22024165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201104133 |
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