Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines

PURPOSE: Acquired resistance to erlotinib in patients with EGFR-mutant non-small cell lung cancer can result from aberrant activation of alternative receptor tyrosine kinases, such as the HGF-driven c-MET receptor. We sought to determine whether inhibition of AKT signaling could augment erlotinib ac...

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Udgivet i:J Cancer Res Clin Oncol
Main Authors: Holland, William S., Chinn, Danielle C., Lara, Primo N., Gandara, David R., Mack, Philip C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562434/
https://ncbi.nlm.nih.gov/pubmed/25323938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-014-1855-4
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