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Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines
PURPOSE: Acquired resistance to erlotinib in patients with EGFR-mutant non-small cell lung cancer can result from aberrant activation of alternative receptor tyrosine kinases, such as the HGF-driven c-MET receptor. We sought to determine whether inhibition of AKT signaling could augment erlotinib ac...
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| Publicado no: | J Cancer Res Clin Oncol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4562434/ https://ncbi.nlm.nih.gov/pubmed/25323938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-014-1855-4 |
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