Population Pharmacokinetic Model Characterizing 24-Hour Variation in the Pharmacokinetics of Oral and Intravenous Midazolam in Healthy Volunteers

Daily rhythms in physiology may affect the pharmacokinetics of a drug. The aim of this study was to evaluate 24-hour variation in the pharmacokinetics of the CYP3A substrate midazolam. Oral (2 mg) and intravenous (1 mg) midazolam was administered at six timepoints throughout the 24-hour period in 12...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: van Rongen, A, Kervezee, L, Brill, MJE, van Meir, H, den Hartigh, J, Guchelaar, H-J, Meijer, JH, Burggraaf, J, van Oosterhout, F
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562161/
https://ncbi.nlm.nih.gov/pubmed/26380154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12007
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