Geranylgeranylacetone selectively binds to the HSP70 of Helicobacter pylori and alters its coccoid morphology

Geranylgeranylacetone (GGA) is used to treat patients suffering from peptic ulcers and gastritis. We examined the effect of GGA on Helicobacter pylori, which is a causative factor of gastrointestinal diseases. Previously, we have reported that GGA binds specifically to the molecular chaperone HSP70....

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Vydáno v:Sci Rep
Hlavní autoři: Grave, Ewa, Yokota, Shin-ichi, Yamamoto, Soh, Tamura, Arisa, Ohtaki-Mizoguchi, Takako, Yokota, Kenji, Oguma, Keiji, Fujiwara, Kazuhiko, Ogawa, Nobuaki, Okamoto, Tomoya, Otaka, Michiro, Itoh, Hideaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561889/
https://ncbi.nlm.nih.gov/pubmed/26345206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13738
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