Geranylgeranylacetone selectively binds to the HSP70 of Helicobacter pylori and alters its coccoid morphology

Geranylgeranylacetone (GGA) is used to treat patients suffering from peptic ulcers and gastritis. We examined the effect of GGA on Helicobacter pylori, which is a causative factor of gastrointestinal diseases. Previously, we have reported that GGA binds specifically to the molecular chaperone HSP70....

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Grave, Ewa, Yokota, Shin-ichi, Yamamoto, Soh, Tamura, Arisa, Ohtaki-Mizoguchi, Takako, Yokota, Kenji, Oguma, Keiji, Fujiwara, Kazuhiko, Ogawa, Nobuaki, Okamoto, Tomoya, Otaka, Michiro, Itoh, Hideaki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561889/
https://ncbi.nlm.nih.gov/pubmed/26345206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13738
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