Loss of phagocytic and antigen cross-presenting capacity in aging DCs is associated with mitochondrial dysfunction

Impaired functionality of dendritic cells (DCs) significantly contributes to decreased adaptive immune responses in aged hosts. The expression of MHC-peptide on the DC surface is the critical first step in T cell priming, but few studies have addressed the effect of aging on antigen (Ag) acquisition...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Immunol
Huvudupphovsmän: Chougnet, Claire A., Thacker, Robert I., Shehata, Hesham M., Hennies, Cassandra M., Lehn, Maria A., Lages, Celine S., Janssen, Edith M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561185/
https://ncbi.nlm.nih.gov/pubmed/26246142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501006
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk