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The aged nonhematopoietic environment impairs natural killer cell maturation and function

Natural killer (NK) cells are critical in eliminating tumors and viral infections, both of which occur at a high incidence in the elderly. Previous studies showed that aged NK cells are less cytotoxic and exhibit impaired maturation compared to young NK cells. We evaluated whether extrinsic or intri...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Shehata, Hesham M, Hoebe, Kasper, Chougnet, Claire A
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364831/
https://ncbi.nlm.nih.gov/pubmed/25677698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12303
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