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Loss of phagocytic and antigen cross-presenting capacity in aging DCs is associated with mitochondrial dysfunction
Impaired functionality of dendritic cells (DCs) significantly contributes to decreased adaptive immune responses in aged hosts. The expression of MHC-peptide on the DC surface is the critical first step in T cell priming, but few studies have addressed the effect of aging on antigen (Ag) acquisition...
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| Опубликовано в: : | J Immunol |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4561185/ https://ncbi.nlm.nih.gov/pubmed/26246142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501006 |
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