Human Neuropsychiatric Disease Modeling Using Conditional Deletion Reveals Synaptic Transmission Defects Caused By Heterozygous Mutations in NRXN1

Heterozygous mutations of the NRXN1 gene, which encodes the presynaptic cell-adhesion molecule neurexin-1, were repeatedly associated with autism and schizophrenia. However, diverse clinical presentations of NRXN1 mutations in patients raise the question whether heterozygous NRXN1 mutations alone di...

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Udgivet i:Cell Stem Cell
Main Authors: Pak, ChangHui, Danko, Tamas, Zhang, Yingsha, Aoto, Jason, Anderson, Garret, Maxeiner, Stephan, Yi, Fei, Wernig, Marius, Südhof, Thomas C.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560990/
https://ncbi.nlm.nih.gov/pubmed/26279266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.07.017
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