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Pathological VWF fibers resist tPA and ADAMTS13 while promoting the contact pathway and shear-induced platelet activation
BACKGROUND: Under severe stenotic conditions, von Willebrand Factor (VWF) multimerizes into large insoluble fibers at pathological shear rates. OBJECTIVE: Evaluate the mechanics and biology of VWF fibers without the confounding effects of endothelium or collagen. METHODS: Within a micropost-impingem...
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| Опубликовано в: : | J Thromb Haemost |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4560981/ https://ncbi.nlm.nih.gov/pubmed/26178390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13044 |
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