The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion

Hepatitis C virus (HCV) assembly is still poorly understood. It is thought that trafficking of the HCV core protein to the lipid droplet (LD) surface is essential for its multimerization and association with newly synthesized HCV RNA to form the viral nucleocapsid. We carried out a mapping analysis...

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Veröffentlicht in:PLoS One
Hauptverfasser: Etienne, Loïc, Blanchard, Emmanuelle, Boyer, Audrey, Desvignes, Virginie, Gaillard, Julien, Meunier, Jean-Christophe, Roingeard, Philippe, Hourioux, Christophe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560444/
https://ncbi.nlm.nih.gov/pubmed/26339783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137182
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