The common LDLR p.G116S variant has a large effect on plasma LDL cholesterol in circumpolar Inuit populations

BACKGROUND: Inuit are considered to be vulnerable to cardiovascular disease (CVD) as their lifestyles become more Westernized. During sequence analysis of Inuit individuals at extremes of lipid traits, we identified two nonsynonymous variants in LDLR encoding the low-density lipoprotein (LDL) recept...

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Detalhes bibliográficos
Publicado no:Circ Cardiovasc Genet
Main Authors: Dubé, Joseph B., Wang, Jian, Cao, Henian, McIntyre, Adam, Johansen, Christopher T., Hopkins, Scarlett E., Stringer, Randa, Hosseinzadeh, Siyavash, Kennedy, Brooke A., Ban, Matthew R., Young, T. Kue, Connelly, Philip W., Dewailly, Eric, Bjerregaard, Peter, Boyer, Bert B., Hegele, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560235/
https://ncbi.nlm.nih.gov/pubmed/25414273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.114.000646
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