Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice

Target-mediated toxicity is a major limitation in the development of chimeric antigen T cell receptors (CAR) for adoptive cell therapy of solid tumors. In this study, we developed a strategy to adjust the affinities of the scFv component of CAR to discriminate tumors overexpressing the target from n...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Liu, Xiaojun, Jiang, Shuguang, Fang, Chongyun, Yang, Shiyu, Olalere, Devvora, Pequignot, Edward C., Cogdill, Alexandria P., Li, Na, Ramones, Melissa, Granda, Brian, Zhou, Li, Loew, Andreas, Young, Regina M., June, Carl H., Zhao, Yangbing
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560113/
https://ncbi.nlm.nih.gov/pubmed/26330166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0159
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