Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes

Genome-wide association studies in Crohn's disease (CD) have identified 140 genome-wide significant loci. However, identification of genes driving association signals remains challenging. Furthermore, genome-wide significant thresholds limit false positives at the expense of decreased sensitivi...

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Udgivet i:Hum Mol Genet
Main Authors: Ning, Kaida, Gettler, Kyle, Zhang, Wei, Ng, Sok Meng, Bowen, B. Monica, Hyams, Jeffrey, Stephens, Michael C., Kugathasan, Subra, Denson, Lee A., Schadt, Eric E., Hoffman, Gabriel E., Cho, Judy H.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Association Studies Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560067/
https://ncbi.nlm.nih.gov/pubmed/25935003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv142
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