Targeted Gene Sequencing in Children with Crohn’s Disease and Their Parents: Implications for Missing Heritability

Crohn’s disease is a complex genetic trait characterized by chronic relapsing intestinal inflammation. Genome wide association studies (GWAS) have identified more than 170 loci associated with the disease, accounting for ∼14% of the disease variance. We hypothesized that rare genetic variation in GW...

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Detalles Bibliográficos
Publicado en:G3 (Bethesda)
Autores principales: Chen, Jiun-Sheng, Hu, Fulan, Kugathasan, Subra, Jorde, Lynn B., Nix, David, Rutherford, Ann, Denson, Lee, Watkins, W. Scott, Prahalad, Sampath, Huff, Chad, Guthery, Stephen L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Genetics Society of America 2018
Materias:
Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118318/
https://ncbi.nlm.nih.gov/pubmed/30166421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.118.200404
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