Crohn’s Disease and Genetic Hitchhiking at IBD5

Inflammatory bowel disease 5 (IBD5) is a 250 kb haplotype on chromosome 5 that is associated with an increased risk of Crohn’s disease in Europeans. The OCTN1 gene is centrally located on IBD5 and encodes a transporter of the antioxidant ergothioneine (ET). The 503F variant of OCTN1 is strongly asso...

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Detalhes bibliográficos
Main Authors: Huff, Chad D., Witherspoon, David J., Zhang, Yuhua, Gatenbee, Chandler, Denson, Lee A., Kugathasan, Subra, Hakonarson, Hakon, Whiting, April, Davis, Chadwick T., Wu, Wilfred, Xing, Jinchuan, Watkins, W. Scott, Bamshad, Michael J., Bradfield, Jonathan P., Bulayeva, Kazima, Simonson, Tatum S., Jorde, Lynn B., Guthery, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245542/
https://ncbi.nlm.nih.gov/pubmed/21816865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msr151
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