Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

The PLA2G6 gene encodes a group VIA calcium-independent phospholipase A2 beta enzyme that selectively hydrolyses glycerophospholipids to release free fatty acids. Mutations in PLA2G6 have been associated with disorders such as infantile neuroaxonal dystrophy, neurodegeneration with brain iron accumu...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Kinghorn, Kerri J., Castillo-Quan, Jorge Iván, Bartolome, Fernando, Angelova, Plamena R., Li, Li, Pope, Simon, Cochemé, Helena M., Khan, Shabana, Asghari, Shabnam, Bhatia, Kailash P., Hardy, John, Abramov, Andrey Y., Partridge, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559908/
https://ncbi.nlm.nih.gov/pubmed/26001724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv132
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