Safety and Immunogenicity of a Dengue Virus Serotype-1 Purified-Inactivated Vaccine: Results of a Phase 1 Clinical Trial

We describe the results from a human clinical trial of a dengue virus serotype-1, purified-inactivated vaccine (DENV-1 PIV) adjuvanted with aluminum hydroxide. This first-in-man, Phase 1, open-label clinical trial consisted of two groups of flavivirus-naïve healthy adult volunteers that received two...

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Bibliographic Details
Published in:Am J Trop Med Hyg
Main Authors: Martinez, Luis Javier, Lin, Leyi, Blaylock, Jason M., Lyons, Arthur G., Bauer, Kristen M., De La Barrera, Rafael, Simmons, Monika, Jarman, Richard G., Currier, Jeffrey R., Friberg, Heather, Danko, Janine R., Teneza-Mora, Nimfa C., Putnak, J. Robert, Eckels, Kenneth H., Thomas, Stephen J.
Format: Artigo
Language:Inglês
Published: The American Society of Tropical Medicine and Hygiene 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559679/
https://ncbi.nlm.nih.gov/pubmed/26149862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.14-0819
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