Safety and Immunogenicity of an AS03(B)-Adjuvanted Inactivated Tetravalent Dengue Virus Vaccine Administered on Varying Schedules to Healthy U.S. Adults: A Phase 1/2 Randomized Study

Dengue disease and its causative agents, the dengue viruses (DENV-1–4), cause high morbidity in tropical and subtropical regions. We evaluated three dosing regimens of the investigational tetravalent AS03(B)-adjuvanted dengue-purified inactivated vaccine (DPIV+AS03(B)). In this phase 1/2, observer-b...

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Publicado en:Am J Trop Med Hyg
Autores principales: Lin, Leyi, Lyke, Kirsten E., Koren, Michael, Jarman, Richard G., Eckels, Kenneth H., Lepine, Edith, McArthur, Monica A., Currier, Jeffrey R., Friberg, Heather, Moris, Philippe, Keiser, Paul B., De La Barrera, Rafael, Vaughn, David W., Paris, Robert M., Thomas, Stephen J., Schmidt, Alexander C.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Tropical Medicine and Hygiene 2020
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356407/
https://ncbi.nlm.nih.gov/pubmed/32342848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.19-0738
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