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ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1
BACKGROUND: The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due to the embryonic lethality of ERK2 k...
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| Publicat a: | BMC Evol Biol |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4559367/ https://ncbi.nlm.nih.gov/pubmed/26336084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-015-0450-x |
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