ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1

BACKGROUND: The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due to the embryonic lethality of ERK2 k...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:BMC Evol Biol
Hlavní autoři: Buscà, Roser, Christen, Richard, Lovern, Matthew, Clifford, Alexander M., Yue, Jia-Xing, Goss, Greg G., Pouysségur, Jacques, Lenormand, Philippe
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559367/
https://ncbi.nlm.nih.gov/pubmed/26336084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-015-0450-x
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky