The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex

Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in cholesterol-containing membranes. Cryo-EM has revealed the structures of the membrane-surface bound pre-pore and inserted-pore o...

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Pubblicato in:Sci Rep
Autori principali: Marshall, Jamie E., Faraj, Bayan H. A., Gingras, Alexandre R., Lonnen, Rana, Sheikh, Md. Arif, El-Mezgueldi, Mohammed, Moody, Peter C. E., Andrew, Peter W., Wallis, Russell
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558608/
https://ncbi.nlm.nih.gov/pubmed/26333773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13293
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