T-cell ligands modulate the cytolytic activity of the CD33/CD3 BiTE antibody construct, AMG 330

Preclinical and emerging clinical studies demonstrate that bispecific T-cell engaging (BiTE) antibody constructs can potently lyse targeted tumor cells, but the determinants for their activity remain incompletely understood. Using human acute myeloid leukemia (AML) cell lines engineered to overexpre...

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Detaylı Bibliyografya
Yayımlandı:Blood Cancer J
Asıl Yazarlar: Laszlo, G S, Gudgeon, C J, Harrington, K H, Walter, R B
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558592/
https://ncbi.nlm.nih.gov/pubmed/26295610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2015.68
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