The Broad Anti-AML Activity of the CD33/CD3 BiTE Antibody Construct, AMG 330, Is Impacted by Disease Stage and Risk

The CD33/CD3-bispecific T-cell engaging (BiTE) antibody construct, AMG 330, potently lyses CD33+ leukemic cells in vitro. Using specimens from 41 patients with acute myeloid leukemia (AML), we studied the factors that might contribute to clinical response or resistance. For this purpose, thawed aliq...

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Bibliographic Details
Published in:PLoS One
Main Authors: Harrington, Kimberly H., Gudgeon, Chelsea J., Laszlo, George S., Newhall, Kathryn J., Sinclair, Angus M., Frankel, Stanley R., Kischel, Roman, Chen, Guang, Walter, Roland B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549148/
https://ncbi.nlm.nih.gov/pubmed/26305211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135945
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