Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis

The mammalian target of rapamycin (mTOR) was recently identified in two structurally distinct multiprotein complexes: mTORC1 and mTORC2. Previously, we found that Rictor/mTORC2 protects against cisplatin-induced acute kidney injury, but the role and mechanisms for Rictor/mTORC2 in TGFβ1-induced fibr...

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Li, Jianzhong, Ren, Jiafa, Liu, Xin, Jiang, Lei, He, Weichun, Yuan, Weiping, Yang, Junwei, Dai, Chunsun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558569/
https://ncbi.nlm.nih.gov/pubmed/25970154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2015.119
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