MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

MYCN amplification occurs in 20% of neuroblastomas and is strongly related to poor clinical outcome. We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this finding experimentally by showing that MYCN ampl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Lau, Diana T., Flemming, Claudia L., Gherardi, Samuele, Perini, Giovanni, Oberthuer, André, Fischer, Matthias, Juraeva, Dilafruz, Brors, Benedikt, Xue, Chengyuan, Norris, Murray D., Marshall, Glenn M., Haber, Michelle, Fletcher, Jamie I., Ashton, Lesley J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2015
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558167/
https://ncbi.nlm.nih.gov/pubmed/25860940
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