MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

MYCN amplification occurs in 20% of neuroblastomas and is strongly related to poor clinical outcome. We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this finding experimentally by showing that MYCN ampl...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lau, Diana T., Flemming, Claudia L., Gherardi, Samuele, Perini, Giovanni, Oberthuer, André, Fischer, Matthias, Juraeva, Dilafruz, Brors, Benedikt, Xue, Chengyuan, Norris, Murray D., Marshall, Glenn M., Haber, Michelle, Fletcher, Jamie I., Ashton, Lesley J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558167/
https://ncbi.nlm.nih.gov/pubmed/25860940
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