Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2′-deoxycytidine in human leukemic KG1 cells

5-azacytidine and 5-aza-2′-deoxycytidine are clinically used to treat patients with blood neoplasia. Their antileukemic property is mediated by the trapping and the subsequent degradation of a family of proteins, the DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B) leading to DNA demethylation, tu...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Vispé, Stéphane, Deroide, Arthur, Davoine, Emeline, Desjobert, Cécile, Lestienne, Fabrice, Fournier, Lucie, Novosad, Natacha, Bréand, Sophie, Besse, Jérôme, Busato, Florence, Tost, Jörg, De Vries, Luc, Cussac, Didier, Riond, Joëlle, Arimondo, Paola B.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558150/
https://ncbi.nlm.nih.gov/pubmed/25948775
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