Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

Sprouting angiogenesis drives blood vessel growth in healthy and diseased tissues. Vegf and Dll4/Notch signalling cooperate in a negative feedback loop that specifies endothelial tip and stalk cells to ensure adequate vessel branching and function. Current concepts posit that endothelial cells defau...

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Publicado en:Nat Commun
Main Authors: Aspalter, Irene Maria, Gordon, Emma, Dubrac, Alexandre, Ragab, Anan, Narloch, Jarek, Vizán, Pedro, Geudens, Ilse, Collins, Russell Thomas, Franco, Claudio Areias, Abrahams, Cristina Luna, Thurston, Gavin, Fruttiger, Marcus, Rosewell, Ian, Eichmann, Anne, Gerhardt, Holger
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557308/
https://ncbi.nlm.nih.gov/pubmed/26081042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8264
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