Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

Sprouting angiogenesis drives blood vessel growth in healthy and diseased tissues. Vegf and Dll4/Notch signalling cooperate in a negative feedback loop that specifies endothelial tip and stalk cells to ensure adequate vessel branching and function. Current concepts posit that endothelial cells defau...

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Publicat a:Nat Commun
Autors principals: Aspalter, Irene Maria, Gordon, Emma, Dubrac, Alexandre, Ragab, Anan, Narloch, Jarek, Vizán, Pedro, Geudens, Ilse, Collins, Russell Thomas, Franco, Claudio Areias, Abrahams, Cristina Luna, Thurston, Gavin, Fruttiger, Marcus, Rosewell, Ian, Eichmann, Anne, Gerhardt, Holger
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557308/
https://ncbi.nlm.nih.gov/pubmed/26081042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8264
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