Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue

Restricted oxygen diffusion can result in central cell necrosis in engineered tissue, a problem that is exacerbated when engineering large tissue constructs for clinical application. Here we show that pre-treating human mesenchymal stem cells (hMSCs) with synthetic membrane-active myoglobin-polymer–...

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Pubblicato in:Nat Commun
Autori principali: Armstrong, James P. K., Shakur, Rameen, Horne, Joseph P., Dickinson, Sally C., Armstrong, Craig T., Lau, Katherine, Kadiwala, Juned, Lowe, Robert, Seddon, Annela, Mann, Stephen, Anderson, J. L. Ross, Perriman, Adam W., Hollander, Anthony P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557285/
https://ncbi.nlm.nih.gov/pubmed/26080734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8405
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