Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue

Restricted oxygen diffusion can result in central cell necrosis in engineered tissue, a problem that is exacerbated when engineering large tissue constructs for clinical application. Here we show that pre-treating human mesenchymal stem cells (hMSCs) with synthetic membrane-active myoglobin-polymer–...

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Vydáno v:Nat Commun
Hlavní autoři: Armstrong, James P. K., Shakur, Rameen, Horne, Joseph P., Dickinson, Sally C., Armstrong, Craig T., Lau, Katherine, Kadiwala, Juned, Lowe, Robert, Seddon, Annela, Mann, Stephen, Anderson, J. L. Ross, Perriman, Adam W., Hollander, Anthony P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557285/
https://ncbi.nlm.nih.gov/pubmed/26080734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8405
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