Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue

Restricted oxygen diffusion can result in central cell necrosis in engineered tissue, a problem that is exacerbated when engineering large tissue constructs for clinical application. Here we show that pre-treating human mesenchymal stem cells (hMSCs) with synthetic membrane-active myoglobin-polymer–...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Armstrong, James P. K., Shakur, Rameen, Horne, Joseph P., Dickinson, Sally C., Armstrong, Craig T., Lau, Katherine, Kadiwala, Juned, Lowe, Robert, Seddon, Annela, Mann, Stephen, Anderson, J. L. Ross, Perriman, Adam W., Hollander, Anthony P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557285/
https://ncbi.nlm.nih.gov/pubmed/26080734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8405
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