Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells

ATP is essential for cellular function and is usually produced through oxidative phosphorylation. However, mitochondrial dysfunction is now being recognized as an important contributing factor in the development cardiovascular diseases, such as pulmonary hypertension (PH). In PH there is a metabolic...

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Vydáno v:Redox Biol
Hlavní autoři: Rafikov, Ruslan, Sun, Xutong, Rafikova, Olga, Louise Meadows, Mary, Desai, Ankit A., Khalpey, Zain, Yuan, Jason X.-J., Fineman, Jeffrey R., Black, Stephen M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556771/
https://ncbi.nlm.nih.gov/pubmed/26298201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.07.016
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