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Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung

BACKGROUND: Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possible role of mitochondrial dysfunction in the pathogenesis of PAH, we investigated...

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Podrobná bibliografie
Vydáno v:Respir Res
Hlavní autoři: Rafikova, Olga, Srivastava, Anup, Desai, Ankit A., Rafikov, Ruslan, Tofovic, Stevan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5914012/
https://ncbi.nlm.nih.gov/pubmed/29685148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-018-0776-1
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