Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells

ATP is essential for cellular function and is usually produced through oxidative phosphorylation. However, mitochondrial dysfunction is now being recognized as an important contributing factor in the development cardiovascular diseases, such as pulmonary hypertension (PH). In PH there is a metabolic...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Rafikov, Ruslan, Sun, Xutong, Rafikova, Olga, Louise Meadows, Mary, Desai, Ankit A., Khalpey, Zain, Yuan, Jason X.-J., Fineman, Jeffrey R., Black, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556771/
https://ncbi.nlm.nih.gov/pubmed/26298201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.07.016
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