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Endothelin ET(A) receptor/lipid peroxides/COX-2/TGF-β1 signalling underlies aggravated nephrotoxicity caused by cyclosporine plus indomethacin in rats

BACKGROUND AND PURPOSE: Cyclosporine (CSA) and non-steroidal anti-inflammatory drugs (NSAIDs) are co-prescribed for some arthritic conditions. We tested the hypothesis that this combined regimen elicits exaggerated nephrotoxicity in rats via the up-regulation of endothelin (ET) receptor signalling....

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Helmy, Maged W, El-Gowelli, Hanan M, Ali, Rabab M, El-Mas, Mahmoud M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556468/
https://ncbi.nlm.nih.gov/pubmed/26013701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13199
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