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Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs

Nephrotoxicity is a major side effect for the antineoplastic drug cisplatin. Here, we employed pharmacological, biochemical, and molecular studies to investigate the role of peroxisome proliferator-activated receptors (PPARs) in cisplatin nephrotoxicity. Rats were treated with a single i.p. dose of...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Helmy, Mai M., Helmy, Maged W., El-Mas, Mahmoud M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633146/
https://ncbi.nlm.nih.gov/pubmed/26536032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142303
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